Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911380 | 0.89 | NOTUM (0.45) | NOTUMRIOK2 | |
| SCHEMBL8911334 | 0.89 | PDE3B (0.40) | RIOK2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7347889 | 0.79 | PARP1 (0.39) | GRIA1GRIA2GRIA3GRIA4MEN1 | |
| SCHEMBL8912871 | 0.78 | NOTUM (0.39) | NOTUMGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8912056 | 0.78 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8911468 | 0.78 | GRIA1 (0.42) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8911793 | 0.77 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8911174 | 0.77 | GRIA1 (0.36) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8911163 | 0.77 | GRIA1 (0.36) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| Hydrochloric Acid SCHEMBL8912261 | 0.76 | GRIA1 (0.36) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0698024-B1 | [1,2,4]TRIAZOLO [4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-01-22 | — | — | EP | claimed |
| US-5532236-A | TREATMENT OF PARKINSON'S DISEASE | NOVO NORDISK A/S (DK) | 1996-07-02 | — | — | US | claimed |
| EP-0698024-B1 | [1,2,4]TRIAZOLO [4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-01-22 | — | — | EP | disclosed |
| US-5532236-A | TREATMENT OF PARKINSON'S DISEASE | NOVO NORDISK A/S (DK) | 1996-07-02 | — | — | US | disclosed |