SCHEMBL8910922

SCHEMBL8910922

C=C(C)C(=O)OCC(O)COc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.38
MAPT P10636 3/20 0.38
NPSR1 Q6W5P4 2/20 0.38
LMNA P02545 1/20 0.38
ADRB2 P07550 2/20 0.34
ADRB1 P08588 1/20 0.34
GSTP1 P09211 2/20 0.34
KMT2A Q03164 4/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
MEN1 O00255 3/20 0.33
HTT P42858 2/20 0.33
MAPK1 P28482 2/20 0.33
APEX1 P27695 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
KDM4E B2RXH2 1/20 0.32
USP2 O75604 1/20 0.32
TP53 P04637 1/20 0.32
ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29512650 0.90 MAPT (0.38) POLBMAPTNPSR1LMNAADRB2
SCHEMBL7128120 0.87 ADRB2 (0.42) POLBMAPTNPSR1LMNAADRB2
SCHEMBL30887231 0.85 HTT (0.43) POLBMAPTNPSR1LMNAGSTP1
SCHEMBL8383168 0.85 HTT (0.43) POLBMAPTNPSR1LMNAGSTP1
SCHEMBL28738069 0.85 LMNA (0.36) POLBMAPTNPSR1LMNAGSTP1
SCHEMBL14867139 0.85 MEN1 (0.41) POLBMAPTNPSR1LMNAGSTP1
SCHEMBL14998027 0.84 ADRB2 (0.34) POLBMAPTNPSR1LMNAADRB2
SCHEMBL30887155 0.84 POLB (0.52) POLBGSTP1HTTAPEX1TDP1
SCHEMBL8385683 0.84 POLB (0.52) POLBGSTP1HTTAPEX1TDP1
SCHEMBL12692546 0.83 MEN1 (0.40) POLBMAPTNPSR1LMNAGSTP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5597854-A PHOTOGRAPHIC APPLICATIONS, COATINGS, BINDERS, POLYMERS, TRIAZINE OR PYRIMIDINE COMPOUNDS CIBA-GEIGY CORPORATION (US) 1997-01-28 US disclosed
EP-0711804-A2 Latent light stabilizers CIBA-GEIGY AG (CH) 1996-05-15 EP disclosed
EP-0441746-B1 Light-stabilised binding agent for coatings CIBA GEIGY AG (CH) 1995-06-21 EP disclosed
US-5356995-A Silicon-containing copolymer, acrylic copolymer, curing agent cabable of reacting with both copolymers, uv rad stabilizer of benzotriazole or triazine derivative copolymerized CIBA-GEIGY CORPORATION (US) 1994-10-18 US disclosed
US-5198498-A Light-stabilized binders for coating compositions CIBA-GEIGY CORPORATION (US) 1993-03-30 US disclosed
EP-0441746-A2 Light-stabilised binding agent for coatings CIBA-GEIGY AG (CH) 1991-08-14 EP disclosed