Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000896 | 0.79 | KMT2A (0.45) | KMT2AGAAMEN1ESR1ESR2 | |
| SCHEMBL8854638 | 0.78 | ALOX15 (0.32) | ALDH1A1MAPTTDP1 | |
| SCHEMBL8854545 | 0.78 | F2 (0.37) | KMT2APOLBALDH1A1HTT | |
| SCHEMBL8854445 | 0.77 | HPGD (0.32) | KMT2AGAAALDH1A1HTTNPSR1 | |
| Butane SCHEMBL1393934 | 0.77 | STAT3 (0.40) | KMT2AGAAMEN1CYP2C19CYP2C9 | |
| SCHEMBL6916199 | 0.75 | KMT2A (0.42) | KMT2AGAAMEN1ESR1ESR2 | |
| SCHEMBL6411427 | 0.75 | KMT2A (0.42) | KMT2AGAAMEN1ESR1ESR2 | |
| SCHEMBL582357 | 0.74 | KMT2A (0.44) | KMT2AGAAMEN1ESR1ESR2 | |
| SCHEMBL8854529 | 0.74 | MEN1 (0.41) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL28684540 | 0.73 | PARL (0.40) | KMT2AGAAPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686629-A | CHEMICAL INTERMEDIATES | GILEAD SCIENCES, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5514798-A | REACTION OF CYCLIC CARBONATE WITH PURINE OR PYRIMIDINE BASE IN SOLVENT AND CRYSTALLIZATION | GILEAD SCIENCES, INC. (US) | 1996-05-07 | — | — | US | disclosed |