Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707643 | 0.85 | KDM4E (0.49) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL8901428 | 0.81 | ESR1 (0.50) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL20410523 | 0.80 | KDM4E (0.50) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL8900361 | 0.80 | HRH3 (0.43) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL20409590 | 0.77 | KDM4E (0.53) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL8901369 | 0.77 | KDM4E (0.42) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL471858 | 0.77 | KDM4E (0.60) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL2678996 | 0.77 | KDM4E (0.46) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL14351661 | 0.76 | KDM4E (0.45) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL954192 | 0.75 | LMNA (0.48) | KDM4ELMNAMAPTHTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686586-A | Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1997-11-11 | — | — | US | disclosed |
| EP-0210929-B1 | AROMATIC POLYCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL AND COSMETIC USE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-06-03 | — | — | EP | disclosed |
| EP-0210929-A2 | Aromatic polycyclic derivatives, process for their preparation and their pharmaceutical and cosmetic use | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1987-02-04 | — | — | EP | disclosed |