Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088974 | 0.85 | KDM4E (0.51) | ESR1ESR2KDM4ELMNAMAPT | |
| SCHEMBL20410523 | 0.82 | KDM4E (0.50) | KDM4EABL1LMNAMAPTHTT | |
| SCHEMBL8911222 | 0.81 | KDM4E (0.43) | KDM4EABL1LMNAMAPTHTT | |
| SCHEMBL20409590 | 0.80 | KDM4E (0.53) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL8901369 | 0.80 | KDM4E (0.42) | KDM4EABL1LMNAMAPTHTT | |
| SCHEMBL2201352 | 0.80 | ESR2 (0.52) | ESR1ESR2KDM4EABL1LMNA | |
| SCHEMBL471858 | 0.79 | KDM4E (0.60) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL19379596 | 0.78 | LMNA (0.44) | KDM4ELMNAMAPTHTTHRH3 | |
| SCHEMBL19287365 | 0.78 | KDM4E (0.43) | ESR1KDM4ELMNAMAPTHTT | |
| SCHEMBL8900361 | 0.77 | HRH3 (0.43) | KDM4EABL1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686586-A | Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1997-11-11 | — | — | US | disclosed |
| US-5602104-A | SKIN DISORDERS, CONJUNCTIVE TISSUE DISORDERS, ANTITUMOR AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1997-02-11 | — | — | US | disclosed |
| US-5434180-A | Skin disorders; retinoid activity; rheumatoid psoriasis; | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1995-07-18 | — | — | US | disclosed |
| US-5124473-A | Skin disorders; antiinflammatory agents, antiallergens | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1992-06-23 | — | — | US | disclosed |
| EP-0210929-B1 | AROMATIC POLYCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL AND COSMETIC USE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-06-03 | — | — | EP | disclosed |
| EP-0210929-A2 | Aromatic polycyclic derivatives, process for their preparation and their pharmaceutical and cosmetic use | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1987-02-04 | — | — | EP | disclosed |