Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8911285 | 1.00 | PGR (0.40) | PGRKMT2AMEN1NPC1KEAP1 | |
| Bicarbonate SCHEMBL8911277 | 0.97 | PGR (0.40) | PGRKMT2AMEN1NPC1KEAP1 | |
| SCHEMBL6571962 | 0.94 | KMT2A (0.43) | PGRKMT2AMEN1NPC1KEAP1 | |
| SCHEMBL8911281 | 0.78 | PGR (0.40) | PGRKMT2AMEN1NPC1CHRNB2 | |
| SCHEMBL8604785 | 0.78 | CYP11B1 (0.42) | KMT2AMEN1NPC1MAOBCHRM2 | |
| SCHEMBL7282122 | 0.77 | PGR (0.39) | PGRKMT2AMEN1NPC1CHRNB2 | |
| SCHEMBL10773101 | 0.76 | CA12 (0.40) | KEAP1NFE2L2CA1CA2HTT | |
| SCHEMBL2707534 | 0.76 | ALDH1A1 (0.48) | KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL204330 | 0.75 | MLYCD (0.40) | HTTMLYCD | |
| SCHEMBL7835897 | 0.75 | BCL2A1 (0.45) | MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |