Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610124 | 0.82 | LMNA (0.61) | LMNAMAPTCYP3A4KDM4ENCOA1 | |
| SCHEMBL7433014 | 0.81 | LMNA (0.70) | LMNAMAPTCYP3A4KDM4ENCOA1 | |
| SCHEMBL710195 | 0.79 | LMNA (0.67) | LMNAMAPTCYP3A4KDM4ENCOA1 | |
| SCHEMBL2361740 | 0.78 | LMNA (0.60) | LMNAMAPTCYP3A4KDM4ENCOA1 | |
| SCHEMBL6513577 | 0.77 | LMNA (1.00) | LMNAMAPTCYP3A4KDM4EHSP90AA1 | |
| SCHEMBL8313 | 0.77 | LMNA (1.00) | LMNAMAPTCYP3A4KDM4EHSP90AA1 | |
| SCHEMBL28527433 | 0.77 | LMNA (0.89) | LMNAMAPTCYP3A4KDM4EHSP90AA1 | |
| Benzoquinone SCHEMBL1512993 | 0.76 | LMNA (0.79) | LMNAMAPTCYP3A4KDM4ENCOA1 | |
| SCHEMBL723791 | 0.76 | LMNA (0.96) | LMNAMAPTCYP3A4KDM4EHSP90AA1 | |
| Iodide SCHEMBL10638043 | 0.76 | LMNA (0.96) | LMNAMAPTCYP3A4KDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085899-B1 | PYRIDOBENZODIAZEPINONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1986-10-29 | — | — | EP | claimed |
| EP-0085893-B1 | PYRIDOBENZODIAZEPINONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1986-05-14 | — | — | EP | claimed |
| EP-0085899-A2 | Pyridobenzodiazepinones, process for their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1983-08-17 | — | — | EP | claimed |
| EP-0085893-A2 | Pyridobenzodiazepinones, process for their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1983-08-17 | — | — | EP | claimed |
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-5593979-A | TREATMENT OF AIDS WITH ENZYME INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0330756-B1 | Thienotricyclics for the treatment of bronchial diseases | BYK GULDEN LOMBERG CHEM FAB (DE) | 1996-03-27 | — | — | EP | disclosed |
| EP-0556947-A1 | Use of M1-selective antimuscarinic pyridobenzodiazepinones for the treatment and prevention of axial myopia | MERCK & CO. INC. (US) | 1993-08-25 | — | — | EP | disclosed |
| EP-0556947-A1 | Use of M1-selective antimuscarinic pyridobenzodiazepinones for the treatment and prevention of axial myopia | MERCK & CO. INC. (US) | 1993-08-25 | — | — | EP | disclosed |
| EP-0556947-A1 | Use of M1-selective antimuscarinic pyridobenzodiazepinones for the treatment and prevention of axial myopia | MERCK & CO. INC. (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1993013777-A1 | METHOD OF USING M1-SELECTIVE ANTIMUSCARINIC PYRIDOBENZODIAZEPINONES IN AXIAL MYOPIA THERAPY | MERCK & CO., INC. (US) | 1993-07-22 | — | — | WO | disclosed |
| WO-1993013777-A1 | METHOD OF USING M1-SELECTIVE ANTIMUSCARINIC PYRIDOBENZODIAZEPINONES IN AXIAL MYOPIA THERAPY | MERCK & CO., INC. (US) | 1993-07-22 | — | — | WO | disclosed |
| WO-1981000568-A1 | BENZODIAZEPINONES,A PROCESS FOR THEIR PREPARATION,THEIR USE AND MEDICAMENTS CONTAINING THEM | BYK GULDEN LOMBERG CHEM FAB (DE) | 1981-03-05 | — | — | WO | disclosed |
| US-4213984-A | ANTIULCER AGENTS, ANTISECRETORY AGENTS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-07-22 | — | — | US | disclosed |
| US-4210648-A | ANTIULCEROGENICS, SECRETION INHIBITORS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-07-01 | — | — | US | disclosed |
| US-4167570-A | BRONCHOSPASMOLYTICS, BRONCHOSECRETOLYTICS | BOEHRINGER INGELHEIM GMBH (DE) | 1979-09-11 | — | — | US | disclosed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |
| US-4021557-A | BRONCHOSPASMOLYTICS | BOEHRINGER INGELHEIM GMBH (DT) | 1977-05-03 | — | — | US | disclosed |
| US-3987197-A | ANTIRHEUMATICS AND ANTIPHLOGISTICS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-10-19 | — | — | US | disclosed |