Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914322 | 0.80 | S1PR5 (0.38) | USP2HRH3LMNAS1PR1S1PR5 | |
| SCHEMBL8947196 | 0.71 | KDM4E (0.45) | LMNAL3MBTL1POLBPKMMAPT | |
| SCHEMBL3748360 | 0.71 | HRH3 (0.39) | HRH3LMNAKMT2AL3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL30028945 | 0.70 | LMNA (0.62) | USP2LMNAOPRK1KMT2AL3MBTL1 | |
| SCHEMBL11094118 | 0.68 | LMNA (0.56) | LMNAS1PR1S1PR5OPRK1KMT2A | |
| SCHEMBL7371335 | 0.68 | LMNA (0.56) | LMNAS1PR1S1PR5OPRK1KMT2A | |
| Hydrochloric Acid SCHEMBL11098029 | 0.67 | CHRM2 (0.56) | USP2LMNAOPRK1KMT2AL3MBTL1 | |
| SCHEMBL22602392 | 0.66 | OPRK1 (0.39) | USP2HRH3OPRK1KMT2AL3MBTL1 | |
| SCHEMBL3252835 | 0.66 | OPRK1 (0.54) | OPRK1POLB | |
| SCHEMBL3252831 | 0.66 | OPRK1 (0.54) | OPRK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641786-A | Quinuclidine derivatives | LOWE III JOHN ADAMS (US) | 1997-06-24 | — | — | US | disclosed |
| US-5422354-A | Quinuclidine derivatives | PFIZER INC (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0540526-B1 | QUINUCLIDINE DERIVATIVES | PFIZER (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0540526-A1 | QUINUCLIDINE DERIVATIVES. | PFIZER (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001688-A1 | QUINUCLIDINE DERIVATIVES | PFIZER INC. (US) | 1992-02-06 | — | — | WO | disclosed |