Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913328 | 0.81 | MAPT (0.38) | MAPTCYP1A2PDE3BPDE3AHRH3 | |
| SCHEMBL8912491 | 0.80 | HDAC3 (0.40) | CYP1A2CYP3A4CYP2C9DYRK1A | |
| SCHEMBL8912991 | 0.78 | ALDH1A1 (0.41) | L3MBTL1CYP1A2GRIA2ALDH1A1 | |
| SCHEMBL8913213 | 0.76 | MAPT (0.39) | MAPTCYP1A2PDE3BPDE3AHRH3 | |
| SCHEMBL8292401 | 0.72 | GRIA2 (0.41) | CYP1A2GRIA2PDE3BPDE3A | |
| SCHEMBL8292411 | 0.71 | PDE3B (0.42) | MAPTCYP1A2GRIA2PDE3BPDE3A | |
| SCHEMBL28527737 | 0.71 | HTT (0.57) | KDM4EMAPTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL8911327 | 0.70 | P2RX7 (0.39) | CYP1A2PDE3BPDE3APARP1PDE4A | |
| Bromide SCHEMBL8298175 | 0.70 | PDE3B (0.41) | MAPTCYP1A2GRIA2PDE3BPDE3A | |
| SCHEMBL8911880 | 0.70 | PDE3B (0.39) | MAPTCYP1A2PDE3BPDE3AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | claimed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | claimed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | claimed |