Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094224 | 0.84 | AGTR1 (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7017110 | 0.80 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL7015549 | 0.79 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL7015176 | 0.77 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL8911478 | 0.76 | CMKLR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9094237 | 0.74 | AGTR1 (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7020747 | 0.74 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL8913756 | 0.73 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL8911592 | 0.72 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL7015525 | 0.72 | AGTR1 (0.41) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |