Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 3/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8913630 | 0.89 | APOBEC3A (0.48) | APOBEC3AAPOBEC3GADRA1DPTAFRHTR1D | |
| Iodide SCHEMBL8913645 | 0.85 | ADRA1D (0.42) | APOBEC3AAPOBEC3GADRA1DPTAFRHTR1D | |
| Iodide SCHEMBL8912933 | 0.83 | PRKD3 (0.44) | APOBEC3AAPOBEC3GCDC25APABPC1PRKCA | |
| SCHEMBL9784234 | 0.82 | APOBEC3A (0.48) | APOBEC3AAPOBEC3GADRA1DPTAFRHTR1D | |
| SCHEMBL7719489 | 0.82 | CDC25A (0.48) | APOBEC3AAPOBEC3GCDC25ALPAR1LPAR3 | |
| Iodide SCHEMBL8912408 | 0.81 | APOBEC3A (0.40) | APOBEC3AAPOBEC3GCDC25APABPC1GAA | |
| Iodide SCHEMBL8915667 | 0.81 | USP2 (0.50) | APOBEC3AAPOBEC3GCDC25APABPC1PLA2G2C | |
| Hydrochloric Acid SCHEMBL7719458 | 0.81 | CDC25A (0.47) | APOBEC3AAPOBEC3GCDC25ALPAR1LPAR3 | |
| SCHEMBL10824014 | 0.79 | CDC25A (0.67) | CDC25AADRA1DPTAFRHTR1DHTR2C | |
| Iodide SCHEMBL10974499 | 0.78 | LMNA (0.57) | APOBEC3AAPOBEC3GADRA1DPTAFRHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614548-A | TREATING TUMORS AND HIV INFECTION, PROTEIN KINASE C INHIBITORS | WAKE FOREST UNIVERSITY (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1990004918-A2 | QUATERNARY AMINE CONTAINING ETHER OR ESTER LIPID DERIVATIVES AND THERAPEUTIC COMPOSITIONS | WAKE FOREST UNIVERSITY (US) | 1990-05-17 | — | — | WO | disclosed |