Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913418 | 0.84 | ALDH1A1 (0.37) | LMNAKDM4EALDH1A1NPSR1MAPT | |
| SCHEMBL9136146 | 0.78 | AGTR1 (0.34) | LMNAKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL9309617 | 0.77 | MAPT (0.34) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL8913223 | 0.77 | AGTR1 (0.49) | AGTR1 | |
| SCHEMBL9137228 | 0.76 | KDM4E (0.33) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL4638846 | 0.75 | ABCG2 (0.46) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL9311085 | 0.74 | FGFR1 (0.38) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL9311096 | 0.74 | AGTR1 (0.33) | AGTR1 | |
| SCHEMBL9135278 | 0.74 | AGTR1 (0.34) | LMNAALDH1A1AGTR1 | |
| SCHEMBL9136773 | 0.74 | ALDH1A1 (0.37) | KDM4EALDH1A1NPSR1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665881-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ANGIOTENSIN II ANTAGONIST | THE GREEN CROSS CORPORATION (JP) | 1997-09-09 | — | — | US | disclosed |
| EP-0569013-B1 | Quinoline compounds as angiotensin II antagonists | GREEN CROSS CORP (JP) | 1996-08-28 | — | — | EP | disclosed |
| EP-0693478-A1 | Quinoline compounds | THE GREEN CROSS CORPORATION (JP) | 1996-01-24 | — | — | EP | disclosed |
| US-5478832-A | Angiotensin II antagonists; cardiovascular disorders | THE GREEN CROSS CORPORATION (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0569013-A1 | Quinoline compounds as angiotensin II antagonists | THE GREEN CROSS CORPORATION (JP) | 1993-11-10 | — | — | EP | disclosed |