SCHEMBL8913612

SCHEMBL8913612

Cc1cc(O)n(CCN)c(=O)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.38
KDM4E B2RXH2 7/20 0.37
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
TDP1 Q9NUW8 2/20 0.37
MAPK1 P28482 2/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37
ALOX12 P18054 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HIF1A Q16665 1/20 0.37
MAPT P10636 4/20 0.36
IDH1 O75874 8/20 0.35
THRB P10828 1/20 0.33
JAK2 O60674 1/20 0.33
JAK1 P23458 1/20 0.33
TYK2 P29597 1/20 0.33
JAK3 P52333 1/20 0.33
HSD17B10 Q99714 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7893096 0.83 KDM4E (0.53) POLBKDM4EMEN1KMT2ATDP1
SCHEMBL10531764 0.83 POLB (0.43) POLBKDM4EMEN1KMT2AMAPT
SCHEMBL11313630 0.80 KDM4E (0.55) POLBKDM4EMEN1KMT2AMAPT
SCHEMBL10533316 0.80 ALDH1A1 (0.49) POLBKDM4EMEN1KMT2ATDP1
SCHEMBL10587273 0.79 ALDH1A1 (0.49) POLBKDM4EMEN1KMT2AMAPK1
SCHEMBL11307884 0.79 ADRA2A (0.48) POLBKDM4EMEN1KMT2AMAPK1
SCHEMBL7883040 0.79 KDM4E (0.52) POLBKDM4EMAPK1MAPTHSD17B10
SCHEMBL11310255 0.79 KDM4E (0.42) POLBKDM4EMEN1KMT2ATDP1
SCHEMBL11326890 0.79 IDH1 (0.37) POLBKDM4EMEN1KMT2ATDP1
SCHEMBL4050261 0.79 POLB (0.55) POLBKDM4EMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5596083-A CELLULOSE, POLYAMIDES, POLYURETHANES OR LEATHER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-01-21 US disclosed
EP-0719840-A1 Monoazo compounds and method for dyeing or printing fiber materials using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-07-03 EP disclosed
EP-0468647-B1 Anionic compounds ZENECA LTD (GB) 1996-03-13 EP disclosed
US-5374301-A Inks suitable for use in ink jet printing ZENECA LIMITED (GB) 1994-12-20 US disclosed
US-5268459-A Anionic azo compound IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-12-07 US disclosed
EP-0468647-A1 Anionic compounds ZENECA LIMITED (GB) 1992-01-29 EP disclosed
US-4283331-A FIBER-REACTIVE DYES CIBA-GEIGY CORPORATION (US) 1981-08-11 US disclosed
US-4243809-A 5-SULFONYL-6-HYDROXYPYRIDONES OR THE 3-CARBAMOYL DERIVATIVES; SULFONYLATION WITH AN ALKYL SULFONYL HALIDE CIBA-GEIGY CORPORATION (US) 1981-01-06 US disclosed
US-4067864-A FOR CELLULOSE OR POLYAMIDES CIBA-GEIGY AG (CH) 1978-01-10 US disclosed