SCHEMBL8913618

SCHEMBL8913618

O=C1CC2(CCN(C(=O)c3ccccc3)CC2)Sc2sc([N+](=O)[O-])cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 3/20 0.42
MAPT P10636 6/20 0.40
ALDH1A1 P00352 5/20 0.40
KMT2A Q03164 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MAPK1 P28482 2/20 0.40
MEN1 O00255 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
LMNA P02545 2/20 0.40
TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8911981 0.78 ALDH1A1 (0.47) CRBNALDH1A1HDAC3HDAC4HDAC1
SCHEMBL471434 0.76 CRBN (0.47) CRBNALDH1A1HDAC3HDAC4HDAC1
SCHEMBL9451740 0.68 HDAC3 (0.52) CRBNMAPTALDH1A1SMN1; SMN2HDAC3
SCHEMBL261598 0.67 HDAC3 (0.67) KMT2AHDAC3HDAC4HDAC1HDAC7
SCHEMBL10659121 0.67 HPGD (0.53) CRBNALDH1A1LMNATP53CA12
SCHEMBL8913631 0.67 TDP1 (0.51) CRBNMAPTALDH1A1KMT2ASMN1; SMN2
SCHEMBL12482094 0.64 ALDH1A1 (0.38) CRBNMAPTALDH1A1SMN1; SMN2MAPK1
SCHEMBL8915943 0.63 HPGD (0.54) CRBNALDH1A1LMNATP53
SCHEMBL10717909 0.62 HPGD (0.58) MAPTALDH1A1SMN1; SMN2CA12CA1
SCHEMBL7129676 0.62 HPGD (0.79) ALDH1A1KMT2AMAPK1MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5633247-A ANTIARRTHYMIA AGENT MERCK & CO., INC. (US) 1997-05-27 US disclosed
US-5206240-A Antiarrhythmia agents MERCK & CO., INC. (US) 1993-04-27 US disclosed
EP-0431943-A2 Nitrogen-containing spirocycles MERCK & CO. INC. (US) 1991-06-12 EP disclosed