Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915943 | 0.82 | HPGD (0.54) | ALDH1A1LMNAHPGDCRBN | |
| SCHEMBL8914593 | 0.72 | NPC1 (0.47) | TDP1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL261598 | 0.70 | HDAC3 (0.67) | TDP1KMT2A | |
| SCHEMBL10659121 | 0.70 | HPGD (0.53) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL18053841 | 0.70 | CA12 (0.61) | ALDH1A1KMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL2390327 | 0.70 | ALDH1A1 (0.76) | TDP1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1845373 | 0.70 | ALDH1A1 (0.67) | TDP1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1842455 | 0.69 | LMNA (0.76) | TDP1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1846736 | 0.69 | TDP1 (0.71) | TDP1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2390062 | 0.69 | TDP1 (0.71) | TDP1ALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |