SCHEMBL8913890

SCHEMBL8913890

CCCCc1nc(Cl)c(CO)n1Cc1ccc2nc(-c3ccccc3C(=O)O)cc(Cl)c2c1.[Na]

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 3/20 0.76
AGTR1 P30556 2/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8913875 0.98 AGTR1 (0.76) AGTR2AGTR1
SCHEMBL8327654 0.93 AGTR1 (0.78) AGTR2AGTR1
SCHEMBL8913879 0.92 AGTR2 (0.66) AGTR2AGTR1
SCHEMBL8326042 0.88 AGTR1 (0.78) AGTR2AGTR1
SCHEMBL8914156 0.87 AGTR1 (0.69) AGTR2AGTR1
SCHEMBL8913280 0.87 AGTR1 (0.77) AGTR2AGTR1
SCHEMBL29486822 0.87 AGTR1 (1.00) AGTR2AGTR1
SCHEMBL89 0.87 AGTR1 (1.00) AGTR2AGTR1
SCHEMBL9468476 0.86 AGTR1 (0.98) AGTR2AGTR1
SCHEMBL8326770 0.85 AGTR2 (0.66) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5665881-A CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ANGIOTENSIN II ANTAGONIST THE GREEN CROSS CORPORATION (JP) 1997-09-09 US disclosed
EP-0693478-A1 Quinoline compounds THE GREEN CROSS CORPORATION (JP) 1996-01-24 EP disclosed
US-5478832-A Angiotensin II antagonists; cardiovascular disorders THE GREEN CROSS CORPORATION (JP) 1995-12-26 US disclosed
EP-0569013-A1 Quinoline compounds as angiotensin II antagonists THE GREEN CROSS CORPORATION (JP) 1993-11-10 EP disclosed