SCHEMBL8326770

SCHEMBL8326770

CCCCc1nc(Cl)c(CO)n1Cc1ccc2nc(-c3ccccc3C(=O)OC)cc(C(=O)OC)c2c1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 3/20 0.66
AGTR1 P30556 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8327654 0.90 AGTR1 (0.78) AGTR2AGTR1
SCHEMBL8914300 0.89 AGTR2 (0.64) AGTR2AGTR1
SCHEMBL462 0.88 AGTR2 (0.80) AGTR2AGTR1
SCHEMBL8326292 0.88 AGTR1 (0.59) AGTR2AGTR1
SCHEMBL8792974 0.86 AGTR2 (0.70) AGTR2AGTR1
SCHEMBL8913890 0.85 AGTR2 (0.76) AGTR2AGTR1
SCHEMBL8913875 0.85 AGTR1 (0.76) AGTR2AGTR1
SCHEMBL8914156 0.84 AGTR1 (0.69) AGTR2AGTR1
SCHEMBL8913879 0.84 AGTR2 (0.66) AGTR2AGTR1
SCHEMBL8792660 0.82 AGTR2 (0.70) AGTR2AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709377-B1 Process for producing quinolin-2-yl benzoic acid compounds ASAHI GLASS CO LTD (JP) 1999-09-29 EP disclosed
US-5780634-A Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds THE GREEN CROSS CORPORATION (JP) 1998-07-14 US disclosed
US-5665881-A CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ANGIOTENSIN II ANTAGONIST THE GREEN CROSS CORPORATION (JP) 1997-09-09 US disclosed
EP-0709377-A1 Process for producing quinolin-2-yl benzoic acid compounds ASAHI GLASS COMPANY LTD. (JP) 1996-05-01 EP disclosed
EP-0693478-A1 Quinoline compounds THE GREEN CROSS CORPORATION (JP) 1996-01-24 EP disclosed
US-5478832-A Angiotensin II antagonists; cardiovascular disorders THE GREEN CROSS CORPORATION (JP) 1995-12-26 US disclosed
EP-0569013-A1 Quinoline compounds as angiotensin II antagonists THE GREEN CROSS CORPORATION (JP) 1993-11-10 EP disclosed