Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.44 |
| ▸ | PRKCG | P05129 | 4/20 | 0.44 |
| ▸ | PRKCB | P05771 | 4/20 | 0.44 |
| ▸ | PRKCA | P17252 | 4/20 | 0.44 |
| ▸ | PRKACA | P17612 | 4/20 | 0.44 |
| ▸ | PRKACG | P22612 | 4/20 | 0.44 |
| ▸ | PRKACB | P22694 | 4/20 | 0.44 |
| ▸ | PRKCH | P24723 | 4/20 | 0.44 |
| ▸ | PRKCI | P41743 | 4/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915915 | 1.00 | ROCK2 (0.45) | ROCK2ROCK1TSHRKDM4ECASP1 | |
| SCHEMBL9539659 | 0.89 | ROCK2 (0.46) | ROCK2ROCK1TSHRKDM4ECASP1 | |
| SCHEMBL8916278 | 0.82 | KDM4E (0.49) | TSHRKDM4ECASP1CASP7HTT | |
| SCHEMBL8914961 | 0.80 | PRKD3 (0.56) | ROCK2ROCK1TSHRKDM4ECASP1 | |
| SCHEMBL8913925 | 0.79 | MMP9 (0.53) | KDM4ESMN1; SMN2HSD17B10HTTLMNA | |
| SCHEMBL2705837 | 0.76 | HCRTR1 (0.64) | TSHRKDM4ECASP1CASP7MEN1 | |
| SCHEMBL2706418 | 0.76 | HCRTR1 (0.64) | TSHRKDM4ECASP1CASP7MEN1 | |
| SCHEMBL8912889 | 0.75 | MMP9 (0.52) | TSHRHTTLMNAALDH1A1 | |
| SCHEMBL7318744 | 0.75 | ROCK2 (0.53) | ROCK2ROCK1TSHRKDM4EPRKD3 | |
| SCHEMBL16712961 | 0.74 | CYP3A4 (0.54) | ROCK2ROCK1TSHRKDM4EPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |