Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913925 | 0.93 | MMP9 (0.53) | MMP9MMP2LMNAALDH1A1HTT | |
| SCHEMBL9540915 | 0.87 | MMP2 (0.54) | MMP9MMP2ATMLMNAALDH1A1 | |
| SCHEMBL893545 | 0.82 | ALDH1A1 (0.66) | ATMLMNAALDH1A1HTTTHRB | |
| SCHEMBL893543 | 0.82 | ALDH1A1 (0.66) | ATMLMNAALDH1A1HTTTHRB | |
| SCHEMBL4653160 | 0.80 | MMP2 (0.76) | MMP9MMP2ALDH1A1HTTGHSR | |
| SCHEMBL1750430 | 0.80 | MMP2 (0.76) | MMP9MMP2ALDH1A1HTTGHSR | |
| SCHEMBL15648472 | 0.79 | ALDH1A1 (0.72) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL6962263 | 0.79 | ALDH1A1 (0.72) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL8916278 | 0.78 | KDM4E (0.49) | LMNAHTTMMP13BCAT2TSHR | |
| SCHEMBL28864063 | 0.78 | LMNA (0.63) | ATMLMNAALDH1A1HTTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |