Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | HTR1D | P28221 | 4/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404720 | 0.85 | HTR6 (0.71) | HTR6SLC6A4LMNAGAAHTR2A | |
| SCHEMBL8416479 | 0.85 | HTR6 (0.71) | HTR6SLC6A4LMNAGAAHTR2A | |
| SCHEMBL25172857 | 0.84 | LMNA (0.76) | HTR6SLC6A4LMNAGAAHTR2A | |
| SCHEMBL10745433 | 0.84 | HTR6 (0.69) | HTR6SLC6A4LMNAGAAHTR2A | |
| SCHEMBL25169578 | 0.84 | CDK4 (0.60) | HTR6SLC6A4LMNAGAAHTR2A | |
| SCHEMBL24723334 | 0.83 | HTR6 (1.00) | HTR6SLC6A4HTR2AHTR1AHTR1D | |
| SCHEMBL2406783 | 0.83 | HTR6 (0.68) | HTR6SLC6A4LMNAGAAHTR2A | |
| SCHEMBL9830738 | 0.82 | HTR6 (0.67) | HTR6SLC6A4LMNAGAAHTR1D | |
| SCHEMBL29471382 | 0.81 | SLC6A4 (0.83) | HTR6SLC6A4HTR2AHTR1AHTR1D | |
| SCHEMBL517473 | 0.81 | SLC6A4 (0.83) | HTR6SLC6A4HTR2AHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| CN-1121348-A | Indole derivatives as 5-H1-like agonists for use in migraine | PFIZER RES & DEV (IE) | 1996-04-24 | — | — | CN | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |