Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12204700 | 0.88 | TRPM8 (0.66) | HTR6SLC6A4TRPM8HTR1DTRPV1 | |
| SCHEMBL9827801 | 0.86 | SLC6A4 (0.58) | HTR6SLC6A4TRPM8HTR1DTRPV1 | |
| SCHEMBL24243716 | 0.84 | SLC6A4 (0.70) | SLC6A4HTR1DSLC6A3 | |
| SCHEMBL1122134 | 0.82 | SLC6A4 (0.85) | HTR6SLC6A4HTR1D | |
| SCHEMBL8914786 | 0.82 | HTR6 (0.71) | HTR6SLC6A4LMNAGAATRPM8 | |
| SCHEMBL2404720 | 0.82 | HTR6 (0.71) | HTR6SLC6A4LMNAGAATRPM8 | |
| SCHEMBL8416479 | 0.82 | HTR6 (0.71) | HTR6SLC6A4LMNAGAATRPM8 | |
| SCHEMBL25172857 | 0.81 | LMNA (0.76) | HTR6SLC6A4LMNAGAATRPM8 | |
| SCHEMBL10745433 | 0.81 | HTR6 (0.69) | HTR6SLC6A4LMNAGAATRPM8 | |
| SCHEMBL4834747 | 0.80 | SLC6A4 (0.59) | HTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225726-B1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-04-17 | — | — | EP | disclosed |
| US-4833153-A | VASOCONSTRICTORS, MIGRAINES | GLAXO GROUP LIMITED (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0225726-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1987-06-16 | — | — | EP | disclosed |
| US-4672067-A | 5-substituted 3-aminoalkyl indoles useful in treatment of migraine | GLAXO GROUP LIMITED (GB) | 1987-06-09 | — | — | US | disclosed |
| US-4252803-A | HYPOTENSIVE AGENTS, ANALGESICS | GLAXO GROUP LIMITED (GB) | 1981-02-24 | — | — | US | disclosed |