Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.53 |
| ▸ | HRH2 | P25021 | 7/20 | 0.53 |
| ▸ | HRH1 | P35367 | 5/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915041 | 0.87 | HRH4 (0.53) | HRH4HRH2HRH1HRH3SMN1; SMN2 | |
| SCHEMBL11158259 | 0.82 | HRH4 (0.51) | HRH4HRH2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8920248 | 0.82 | HRH4 (0.48) | HRH4SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL8920947 | 0.81 | HRH4 (0.45) | HRH4HRH2ALDH1A1KMT2ANAMPT | |
| SCHEMBL11160337 | 0.81 | MEN1 (0.47) | HRH4SMN1; SMN2KMT2ANAMPTMEN1 | |
| SCHEMBL8916134 | 0.80 | HRH4 (0.42) | HRH4HRH2HRH3ALDH1A1KMT2A | |
| SCHEMBL11157679 | 0.80 | NAMPT (0.57) | ALDH1A1KMT2AHTTNAMPTMEN1 | |
| SCHEMBL8916216 | 0.80 | HRH4 (0.48) | HRH4HRH2HRH1HRH3SMN1; SMN2 | |
| SCHEMBL504426 | 0.79 | HRH4 (0.42) | HRH4HRH2HRH3ALDH1A1KMT2A | |
| SCHEMBL504383 | 0.79 | HRH4 (0.42) | HRH4HRH2HRH3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| US-5563160-A | NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-10-08 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |
| EP-0660823-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006770-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-03-31 | — | — | WO | disclosed |