Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460057 | 0.87 | ADRA2C (0.53) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL607964 | 0.84 | NPC1 (0.67) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL10099720 | 0.83 | MEN1 (0.62) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL1208763 | 0.83 | NPC1 (0.69) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL9809230 | 0.83 | NPC1 (0.69) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL4574813 | 0.83 | NPC1 (0.49) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL817611 | 0.82 | NPC1 (0.59) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL28132503 | 0.81 | NPC1 (0.51) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL28142261 | 0.81 | NPC1 (0.51) | ADRA2CNPC1JAK2RAB9APAX8 | |
| SCHEMBL18358943 | 0.81 | HRH3 (0.48) | ADRA2CNPC1JAK2RAB9APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624917-A | Method of inhibiting squalene synthetase | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| EP-0541037-A2 | Squalene synthetase inhibitory composition and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |