Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | XBP1 | P17861 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915354 | 0.96 | L3MBTL1 (0.59) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8915664 | 0.92 | L3MBTL1 (0.58) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8916892 | 0.91 | L3MBTL1 (0.56) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8052257 | 0.91 | L3MBTL1 (0.56) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8917236 | 0.91 | L3MBTL1 (0.56) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8916068 | 0.91 | L3MBTL1 (0.56) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8916496 | 0.91 | L3MBTL1 (0.56) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8915349 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL8914946 | 0.85 | BCL6 (0.66) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 | |
| SCHEMBL6814444 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2NPSR1XBP1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| US-5563160-A | NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-10-08 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |
| EP-0660823-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006770-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-03-31 | — | — | WO | disclosed |