Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL9189671 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL276988 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL2235356 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL3657 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL11060179 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL215569 | 0.97 | CA4 (0.89) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL715802 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL25212993 | 0.94 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL10692975 | 0.94 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL10692967 | 0.94 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217632-A | Stirring a mixture of alpha hydroxy carboxylate, a polyol and water to uniformity, adding boric acid or borax to farm chelate and basification | ZIRCONIUM TECHNOLOGY CORPORATION (US) | 1993-06-08 | — | — | US | claimed |
| EP-0302544-B1 | HIGH TEMPERATURE GUAR-BASED FRACTURING FLUID | PUMPTECH N.V. (BE) | 1992-06-03 | — | — | EP | claimed |
| EP-0302544-A2 | High temperature guar-based fracturing fluid | PUMPTECH N.V. (BE) | 1989-02-08 | — | — | EP | claimed |
| US-4801389-A | ZIRCONIUM OR HAFNIUM CROSSLINKING AGENT, BICARBONATE SALT | DOWELL SCHLUMBERGER INCORPORATED (US) | 1989-01-31 | — | — | US | claimed |
| US-4624795-A | Aqueous acid gels and use thereof | BJ-TITAN SERVICES COMPANY (US) | 1986-11-25 | — | — | US | claimed |
| US-20250298177-A1 | POLARIZING PLATE AND OPTICAL DISPLAY APPARATUS COMPRISING THE SAME | Wuxi Hengxin Optoelectronic Materials Co., Ltd. (CN) | 2025-09-25 | — | — | US | disclosed |
| EP-4601775-A1 | METHODS OF MAKING SHAPE STABLE PHASE CHANGE MATERIAL COMPOSITIONS | Phase Change Energy Solutions, Inc. (US) | 2025-08-20 | — | — | EP | disclosed |
| EP-3597670-B1 | WATER-SOLUBLE COMPOSITION, PRODUCTION METHOD FOR CURED PRODUCT THEREOF, AND CURED PRODUCT THEREOF, AND ACYL PHOSPHINATE | ADEKA CORP (JP) | 2024-07-10 | — | — | EP | disclosed |
| WO-2024102900-A1 | METHODS OF MAKING SHAPE STABLE PHASE CHANGE MATERIAL COMPOSITIONS | PHASE CHANGE ENERGY SOLUTIONS, INC. (US) | 2024-05-16 | — | — | WO | disclosed |
| CN-110036343-B | Water-soluble composition, pattern forming agent, method for producing cured product using same, and cured product | 株式会社ADEKA | 2023-06-13 | — | — | CN | disclosed |
| US-11649334-B2 | Water-soluble composition, production method for cured product thereof, and cured product thereof, and acyl phosphinate | ADEKA CORPORATION (JP) | 2023-05-16 | — | — | US | disclosed |
| CN-110337454-B | Water-soluble composition, method for producing cured product thereof, and acylphosphinate | 株式会社ADEKA | 2022-04-12 | — | — | CN | disclosed |
| US-5268030-A | Containing alpha-hydroxycarboxylic acid ligands | SEQUA CHEMICALS INC. (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0562821-A1 | Paper coating composition containing a zirconium chelate insolubilizer | SEQUA CHEMICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| US-5217632-A | Stirring a mixture of alpha hydroxy carboxylate, a polyol and water to uniformity, adding boric acid or borax to farm chelate and basification | ZIRCONIUM TECHNOLOGY CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |
| US-5182408-A | Process for preparation of stable aqueous solutions of zirconium chelates | ZIRCONIUM TECHNOLOGY CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0302544-B1 | HIGH TEMPERATURE GUAR-BASED FRACTURING FLUID | PUMPTECH N.V. (BE) | 1992-06-03 | — | — | EP | disclosed |
| EP-0302544-A2 | High temperature guar-based fracturing fluid | PUMPTECH N.V. (BE) | 1989-02-08 | — | — | EP | disclosed |
| US-4801389-A | ZIRCONIUM OR HAFNIUM CROSSLINKING AGENT, BICARBONATE SALT | DOWELL SCHLUMBERGER INCORPORATED (US) | 1989-01-31 | — | — | US | disclosed |
| US-4624795-A | Aqueous acid gels and use thereof | BJ-TITAN SERVICES COMPANY (US) | 1986-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649334-B2 | Water-soluble composition, production method for cured product thereof, and cured product thereof, and acyl phosphinate | PHOSPHO1, ASS1, SGMS1 | CA4 895/4885CASP1 2001/4885FFAR3 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.