Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2678377 | 0.98 | ALDH1A1 (0.79) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL16564081 | 0.94 | ALDH1A1 (0.81) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL30602595 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL433102 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL17256326 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL31005435 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL14921878 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL16387329 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MAPTKMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL7153037 | 0.84 | HPGD (0.70) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3101921 | 0.83 | ALDH1A1 (0.60) | ALDH1A1MAPTKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624917-A | Method of inhibiting squalene synthetase | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| EP-0541037-A2 | Squalene synthetase inhibitory composition and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |