SCHEMBL8916428

SCHEMBL8916428

CCc1sc2c(c1CCN1CCC(c3csc4cc(F)ccc34)CC1)CCN(C(C)=O)C2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 4/20 0.49
DRD2 P14416 7/20 0.39
SLC6A4 P31645 4/20 0.39
TP53 P04637 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
RBP4 P02753 3/20 0.37
MCHR1 Q99705 3/20 0.36
HTR2A P28223 4/20 0.35
HTR7 P34969 3/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
KCNH2 Q12809 2/20 0.34
SLC22A2 O15244 1/20 0.34
CACNA1F O60840 1/20 0.34
ADRB2 P07550 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34
HTR1A P08908 1/20 0.34
CHRM5 P08912 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8916709 0.95 CTSS (0.49) CTSSDRD2SLC6A4TP53GAA
Hydrochloric Acid SCHEMBL8920486 0.94 CTSS (0.48) CTSSDRD2SLC6A4TP53GAA
SCHEMBL8915757 0.92 CTSS (0.51) CTSSDRD2SLC6A4TP53GAA
SCHEMBL8917783 0.90 CTSS (0.50) CTSSDRD2SLC6A4TP53GAA
SCHEMBL8915726 0.86 CTSS (0.40) CTSSDRD2SLC6A4TP53MAPT
SCHEMBL8916920 0.83 CTSS (0.41) CTSSDRD2TP53GAAMAPT
SCHEMBL8920271 0.82 DRD2 (0.56) DRD2SLC6A4HTR2AHTR7KCNH2
SCHEMBL8919123 0.81 DRD2 (0.39) CTSSDRD2SLC6A4TP53MAPT
Oxalic Acid SCHEMBL8991806 0.81 CTSS (0.40) CTSSDRD2TP53GAAMAPT
SCHEMBL8919136 0.81 CTSS (0.40) CTSSTP53GAAMAPTMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691330-A ANTIPSYCHOTIC AGENT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-11-25 US disclosed
US-5532240-A ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1996-07-02 US disclosed
EP-0596125-A1 CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-05-11 EP disclosed