Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235959 | 0.89 | PTGS2 (0.53) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8916673 | 0.89 | PTGS2 (0.44) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8917466 | 0.88 | PTGS2 (0.41) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8916712 | 0.88 | PTGS2 (0.41) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8919630 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL8919075 | 0.87 | PTGS2 (0.40) | PTGS2CYP2C9PTGS1ALOX5PIK3CD | |
| SCHEMBL8921429 | 0.86 | PTGS2 (0.42) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8918771 | 0.86 | PTGS2 (0.35) | PTGS2CYP2C9PTGS1ALOX5PIK3CD | |
| SCHEMBL8918829 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL8917212 | 0.85 | PTGS2 (0.42) | PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |