Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917466 | 0.86 | PTGS2 (0.41) | PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL8917301 | 0.85 | PTGS2 (0.45) | PTGS2PIK3CDPIK3CAPIK3CBALOX5 | |
| SCHEMBL8916673 | 0.84 | PTGS2 (0.44) | PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL8919630 | 0.84 | PTGS2 (0.44) | PTGS2PIK3CDPIK3CAPIK3CBPTGS1 | |
| SCHEMBL8916712 | 0.84 | PTGS2 (0.41) | PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL8917212 | 0.83 | PTGS2 (0.42) | PTGS2ALOX5 | |
| SCHEMBL8917653 | 0.83 | CYP1A2 (0.48) | PTGS2CYP1A2CYP2D6GRIA2CYP2C9 | |
| SCHEMBL8919075 | 0.83 | PTGS2 (0.40) | PTGS2PIK3CDPIK3CAPIK3CBALOX5 | |
| SCHEMBL8921429 | 0.82 | PTGS2 (0.42) | PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL8918771 | 0.82 | PTGS2 (0.35) | PTGS2PIK3CDPIK3CAPIK3CBALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |
| WO-1996009293-A1 | BENZ[g]INDAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |