SCHEMBL8917381

SCHEMBL8917381

N#Cc1cccnc1NC(C(N)=O)c1c(Cl)cccc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.45
HPGD P15428 6/20 0.45
SMN1; SMN2 Q16637 4/20 0.43
KDM4E B2RXH2 4/20 0.43
NPC1 O15118 4/20 0.41
RAB9A P51151 4/20 0.41
POLB P06746 1/20 0.41
GAA P10253 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
RECQL P46063 1/20 0.39
GRM4 Q14833 1/20 0.37
CYP1A2 P05177 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
CYP3A4 P08684 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
S1PR1 P21453 2/20 0.35
S1PR3 Q99500 2/20 0.35
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8918710 0.78 HPGD (0.64) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1
SCHEMBL8916681 0.77 ITGB1 (0.44) ALDH1A1SMN1; SMN2NPC1RAB9ACYP1A2
SCHEMBL8917760 0.75 DHODH (0.36) ALDH1A1SMN1; SMN2NPC1RAB9AGAA
SCHEMBL1253969 0.70 ALDH1A1 (0.63) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1
SCHEMBL31324770 0.70 ALDH1A1 (0.63) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1
SCHEMBL1848870 0.68 NPC1 (0.48) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1
SCHEMBL3392697 0.68 HPGD (0.69) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1
SCHEMBL11210924 0.67 NPC1 (0.44) ALDH1A1HPGDNPC1GAALMNA
SCHEMBL17500003 0.67 HPGD (0.51) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1
SCHEMBL2801672 0.66 HPGD (0.47) ALDH1A1HPGDSMN1; SMN2KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5480997-A VIRICIDE FOR HIV JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-02 US claimed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP claimed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO claimed
US-5604230-A USEFUL IN INHIBITING THE REPLICATION OF HIV JANSSEN PHARMACEUTICA N.V. (BE) 1997-02-18 US disclosed
US-5587387-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-12-24 US disclosed
US-5552430-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-03 US disclosed
US-5550135-A ANTIRETROVIRAL AGENTS; TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-27 US disclosed
US-5541215-A ANTIRETROVIRAL COMPOUNDS; TREATING HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-07-30 US disclosed
US-5480997-A VIRICIDE FOR HIV JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-02 US disclosed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP disclosed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO disclosed