SCHEMBL8917760

SCHEMBL8917760

CC(=O)c1nccnc1NC(C(N)=O)c1c(Cl)cccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
CXCL8 P10145 1/20 0.33
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
SCD O00767 2/20 0.32
SYK P43405 1/20 0.32
TOP1 P11387 1/20 0.32
MAPT P10636 1/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
TSHR P16473 1/20 0.32
RPS6KB1 P23443 2/20 0.31
PIK3CD O00329 2/20 0.31
PIK3R2 O00459 2/20 0.31
AURKA O14965 1/20 0.31
PIK3CG P48736 1/20 0.31
JAK2 O60674 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8917175 0.83 DHODH (0.38) DHODHSMN1; SMN2ALDH1A1GAANPC1
SCHEMBL8917381 0.75 ALDH1A1 (0.45) DHODHSMN1; SMN2ALDH1A1GAANPC1
SCHEMBL8916681 0.74 ITGB1 (0.44) SMN1; SMN2ALDH1A1NPC1RAB9AMAPT
SCHEMBL8830164 0.72 KDM4E (0.43) SMN1; SMN2ALDH1A1CXCL8NPC1RAB9A
SCHEMBL8830304 0.69 GRIK1 (0.39) SMN1; SMN2ALDH1A1GAACXCL8NPC1
SCHEMBL11210924 0.69 NPC1 (0.44) ALDH1A1GAANPC1MAPTTSHR
Loviride SCHEMBL29456999 0.68 ALOX15 (0.39) SMN1; SMN2ALDH1A1GAANPC1RAB9A
Loviride SCHEMBL29457001 0.68 ALOX15 (0.39) SMN1; SMN2ALDH1A1GAANPC1RAB9A
Loviride SCHEMBL247782 0.68 ALOX15 (0.39) SMN1; SMN2ALDH1A1GAANPC1RAB9A
Loviride SCHEMBL247781 0.68 ALOX15 (0.39) SMN1; SMN2ALDH1A1GAANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1034074-C Heterocycle-substituted benzenemethanamine derivatives JANSSEN PHARMACEUTICA NV (BE) 1997-02-19 CN claimed
US-5604230-A USEFUL IN INHIBITING THE REPLICATION OF HIV JANSSEN PHARMACEUTICA N.V. (BE) 1997-02-18 US claimed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP claimed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO claimed
CN-1073942-A The benzenemethanamine derivatives of heterocyclic substituted JANSSEN PHARMACEUTICA NV (BE) 1993-07-07 CN claimed
CN-1034074-C Heterocycle-substituted benzenemethanamine derivatives JANSSEN PHARMACEUTICA NV (BE) 1997-02-19 CN disclosed
US-5604230-A USEFUL IN INHIBITING THE REPLICATION OF HIV JANSSEN PHARMACEUTICA N.V. (BE) 1997-02-18 US disclosed
US-5587387-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-12-24 US disclosed
US-5552430-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-03 US disclosed
US-5550135-A ANTIRETROVIRAL AGENTS; TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-27 US disclosed
US-5541215-A ANTIRETROVIRAL COMPOUNDS; TREATING HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-07-30 US disclosed
US-5480997-A VIRICIDE FOR HIV JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-02 US disclosed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP disclosed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO disclosed
CN-1073942-A The benzenemethanamine derivatives of heterocyclic substituted JANSSEN PHARMACEUTICA NV (BE) 1993-07-07 CN disclosed