SCHEMBL8916681

SCHEMBL8916681

NC(=O)C(Nc1ncccc1[N+](=O)[O-])c1c(Cl)cccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 1/20 0.44
ITGA4 P13612 1/20 0.44
MAPT P10636 7/20 0.42
KMT2A Q03164 3/20 0.41
LMNA P02545 1/20 0.41
ALDH1A1 P00352 4/20 0.41
DPP4 P27487 1/20 0.41
DPP7 Q9UHL4 1/20 0.41
NPC1 O15118 6/20 0.40
RAB9A P51151 6/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
NFKB1 P19838 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL377354 0.80 MAPT (0.46) MAPTKMT2ALMNAALDH1A1NPC1
SCHEMBL29456982 0.80 MAPT (0.46) MAPTKMT2ALMNAALDH1A1NPC1
SCHEMBL9246536 0.80 MAPT (0.46) MAPTKMT2ALMNAALDH1A1NPC1
SCHEMBL8918547 0.80 MEN1 (0.44) ITGB1ITGA4MAPTKMT2ALMNA
SCHEMBL8917381 0.77 ALDH1A1 (0.45) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL8830256 0.75 TSHR (0.43) MAPTKMT2ALMNAALDH1A1SMN1; SMN2
SCHEMBL8917760 0.74 DHODH (0.36) MAPTALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL7697932 0.74 MAPT (0.51) MAPTKMT2ALMNAALDH1A1DPP4
SCHEMBL27993393 0.74 ALDH1A1 (0.55) ITGB1ITGA4MAPTKMT2ALMNA
SCHEMBL8830303 0.73 MAPT (0.42) MAPTKMT2ALMNAALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5480997-A VIRICIDE FOR HIV JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-02 US claimed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP claimed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO claimed
US-5604230-A USEFUL IN INHIBITING THE REPLICATION OF HIV JANSSEN PHARMACEUTICA N.V. (BE) 1997-02-18 US disclosed
US-5587387-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-12-24 US disclosed
US-5552430-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-03 US disclosed
US-5550135-A ANTIRETROVIRAL AGENTS; TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-27 US disclosed
US-5541215-A ANTIRETROVIRAL COMPOUNDS; TREATING HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-07-30 US disclosed
US-5480997-A VIRICIDE FOR HIV JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-02 US disclosed