Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8915892 | 0.92 | MCL1 (0.36) | PNMTMCL1ACMSDHTR7HTR1A | |
| SCHEMBL27950640 | 0.77 | MAPT (0.49) | MCL1ACMSDMMP12MMP13SLC6A2 | |
| SCHEMBL29009022 | 0.76 | CA12 (0.38) | MCL1ACMSDMMP12MMP13SLC6A2 | |
| SCHEMBL29009007 | 0.76 | CA12 (0.40) | MCL1ACMSDMMP12MMP13CYP1A2 | |
| Hydrochloric Acid SCHEMBL5348072 | 0.75 | PNMT (0.68) | PNMTDRD2DRD4DRD3HTR7 | |
| Hydrochloric Acid SCHEMBL27463386 | 0.75 | MCL1 (0.38) | MCL1ACMSDHTR7HTR1AGPR84 | |
| Hydrochloric Acid SCHEMBL27551952 | 0.75 | MCL1 (0.38) | MCL1ACMSDHTR7HTR1AGPR84 | |
| SCHEMBL3137217 | 0.74 | MCL1 (0.47) | MCL1ACMSDCYP2C9CYP2C19KDM4E | |
| SCHEMBL29785059 | 0.74 | MCL1 (0.47) | MCL1ACMSDCYP2C9CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL9245137 | 0.72 | PNMT (0.68) | PNMTDRD2DRD4DRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668230-A | METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-09-16 | — | — | US | claimed |