Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ly-2874455. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 known ✓ | P22455 | 13/20 | 0.98 |
| ▸ | FGFR1 known ✓ | P11362 | 6/20 | 0.98 |
| ▸ | FGFR2 known ✓ | P21802 | 4/20 | 0.98 |
| ▸ | FGFR3 known ✓ | P22607 | 3/20 | 0.98 |
| ▸ | KDR | P35968 | 4/20 | 0.98 |
| ▸ | ETV6 | P41212 | 3/20 | 0.98 |
| ▸ | AURKA | O14965 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ly-2874455 SCHEMBL891769 | 1.00 | FGFR4 (0.98) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL891766 | 1.00 | FGFR4 (0.98) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL891767 | 1.00 | FGFR4 (0.98) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL298445 | 0.99 | FGFR4 (1.00) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL29627000 | 0.99 | FGFR4 (1.00) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL298446 | 0.99 | FGFR4 (1.00) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL297689 | 0.99 | FGFR4 (1.00) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| Ly-2874455 SCHEMBL297690 | 0.99 | FGFR4 (1.00) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| SCHEMBL19821102 | 0.92 | FGFR4 (0.86) | FGFR4FGFR1FGFR2KDRFGFR3 | |
| SCHEMBL16921051 | 0.92 | FGFR4 (0.86) | FGFR4FGFR1FGFR2KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2625175-B1 | CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL AND ITS USE AS FGFR INHIBITOR | LILLY CO ELI (US) | 2015-11-18 | — | — | EP | claimed |
| US-8530665-B2 | Crystalline (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol | ELI LILLY AND COMPANY (US) | 2013-09-10 | — | — | US | claimed |
| US-20120083511-A1 | CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL | ELI LILLY AND COMPANY (US) | 2012-04-05 | — | — | US | claimed |
| EP-2625175-B1 | CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL AND ITS USE AS FGFR INHIBITOR | LILLY CO ELI (US) | 2015-11-18 | — | — | EP | disclosed |
| US-8530665-B2 | Crystalline (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol | ELI LILLY AND COMPANY (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120083511-A1 | CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL | ELI LILLY AND COMPANY (US) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083511-A1 | CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL | ADH1A, ADH1C, ADH5 | FGFR4 361/4885FGFR1 112/4885FGFR2 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.