Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916681 | 0.80 | ITGB1 (0.44) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL12890441 | 0.80 | KMT2A (0.52) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL9016031 | 0.78 | MAPT (0.50) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL7697932 | 0.77 | MAPT (0.51) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL12985610 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL8916607 | 0.75 | DHODH (0.45) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL16721275 | 0.74 | MAPT (0.50) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL16721273 | 0.74 | MAPT (0.50) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL31477687 | 0.74 | KMT2A (0.52) | MEN1KMT2AL3MBTL1MAPTNPC1 | |
| SCHEMBL1669347 | 0.74 | KMT2A (0.52) | MEN1KMT2AL3MBTL1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620811-A1 | HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-10-26 | — | — | EP | claimed |
| WO-1993013069-A1 | HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-08 | — | — | WO | claimed |
| US-5604230-A | USEFUL IN INHIBITING THE REPLICATION OF HIV | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-18 | — | — | US | disclosed |
| US-5587387-A | ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-12-24 | — | — | US | disclosed |
| US-5552430-A | ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| US-5550135-A | ANTIRETROVIRAL AGENTS; TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-27 | — | — | US | disclosed |
| US-5541215-A | ANTIRETROVIRAL COMPOUNDS; TREATING HIV INFECTIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-30 | — | — | US | disclosed |
| US-5480997-A | VIRICIDE FOR HIV | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-02 | — | — | US | disclosed |
| EP-0620811-A1 | HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993013069-A1 | HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-08 | — | — | WO | disclosed |