Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917175 | 0.82 | DHODH (0.38) | DHODHMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8790511 | 0.77 | CYP1A2 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1MT-CO2 | |
| SCHEMBL8918547 | 0.75 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL8918710 | 0.74 | HPGD (0.64) | SMN1; SMN2L3MBTL1RAB9ANPC1GAA | |
| SCHEMBL12990441 | 0.71 | KMT2A (0.46) | DHODHMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL16388912 | 0.69 | DHODH (0.47) | DHODHMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL19791389 | 0.69 | RAB9A (0.43) | DHODHMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL16414490 | 0.69 | ALDH1A1 (0.44) | MEN1KMT2ASMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL16616388 | 0.69 | RAB9A (0.76) | DHODHMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL16616153 | 0.69 | MEN1 (0.62) | DHODHMEN1KMT2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480997-A | VIRICIDE FOR HIV | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-02 | — | — | US | claimed |
| US-5604230-A | USEFUL IN INHIBITING THE REPLICATION OF HIV | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-02-18 | — | — | US | disclosed |
| US-5587387-A | ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-12-24 | — | — | US | disclosed |
| US-5552430-A | ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-03 | — | — | US | disclosed |
| US-5550135-A | ANTIRETROVIRAL AGENTS; TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-27 | — | — | US | disclosed |
| US-5541215-A | ANTIRETROVIRAL COMPOUNDS; TREATING HIV INFECTIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-30 | — | — | US | disclosed |
| US-5480997-A | VIRICIDE FOR HIV | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-02 | — | — | US | disclosed |
| EP-0620811-A1 | HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993013069-A1 | HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-08 | — | — | WO | disclosed |