Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391702 | 1.00 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| SCHEMBL2624926 | 1.00 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| SCHEMBL14436556 | 1.00 | KCNA5 (0.67) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| Hydrochloric Acid SCHEMBL5949068 | 0.99 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| Hydrochloric Acid SCHEMBL1762340 | 0.99 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| Hydrochloric Acid SCHEMBL2953561 | 0.99 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| Hydrochloric Acid SCHEMBL1762321 | 0.99 | KCNA5 (0.66) | KCNA5SCN5AKDM4EALDH1A1TACR1 | |
| SCHEMBL14434183 | 0.85 | KCNA5 (0.71) | KCNA5SCN5ASLC6A4KCNH2 | |
| SCHEMBL12810312 | 0.82 | KCNA5 (0.71) | KCNA5SCN5ASLC6A4KCNH2 | |
| SCHEMBL2624922 | 0.82 | KCNA5 (0.71) | KCNA5SCN5AKDM4EALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188140-B2 | Uses of ion channel modulating compounds | CARDIOME PHARMA CORP. | 2012-05-29 | — | — | US | disclosed |
| US-8188140-B2 | Uses of ion channel modulating compounds | CARDIOME PHARMA CORP. | 2012-05-29 | — | — | US | disclosed |
| US-20110118329-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2011-05-19 | — | — | US | disclosed |
| US-20110118329-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2011-05-19 | — | — | US | disclosed |
| US-20070190156-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070190156-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | KCNA5 26/4885SCN5A 54/4885KDM4E 2163/4885 |
| US-20110118329-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | KCNN1, KCNN2, KCNN3 | KCNA5 48/4885SCN5A 49/4885KDM4E 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.