Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920883 | 0.90 | LMNA (0.64) | LMNAL3MBTL1KDM4EGAAGLA | |
| SCHEMBL3455972 | 0.87 | LMNA (0.73) | LMNAL3MBTL1KDM4EGAAGLA | |
| SCHEMBL18757024 | 0.83 | HTT (0.53) | LMNAL3MBTL1KDM4EGAAGLA | |
| SCHEMBL8901755 | 0.82 | LMNA (0.58) | LMNAL3MBTL1KDM4EGAAGLA | |
| SCHEMBL16276100 | 0.79 | LMNA (0.62) | LMNAL3MBTL1KDM4EGAAGLA | |
| SCHEMBL16276094 | 0.79 | LMNA (0.62) | LMNAL3MBTL1KDM4EGAAGLA | |
| SCHEMBL12172755 | 0.78 | ALDH1A1 (0.64) | LMNAL3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL7637491 | 0.77 | L3MBTL1 (0.60) | LMNAL3MBTL1KDM4EPOLBALDH1A1 | |
| SCHEMBL3086784 | 0.75 | ALDH1A1 (0.51) | LMNAL3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL21084414 | 0.75 | ALDH1A1 (1.00) | LMNAL3MBTL1KDM4EGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |