Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | AR | P10275 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15160578 | 0.85 | KDM4E (0.53) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL17073125 | 0.81 | ALDH1A1 (0.67) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL7532567 | 0.80 | RAB9A (0.73) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL17014749 | 0.78 | KDM4E (1.00) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL28491325 | 0.78 | KDM4E (0.75) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL14531231 | 0.78 | KDM4E (0.75) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL18590594 | 0.78 | ALDH1A1 (0.69) | KDM4EARMEN1MAPTKMT2A | |
| SCHEMBL23657508 | 0.77 | KDM4E (0.58) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL6200582 | 0.77 | PTGS2 (0.59) | KDM4EMEN1MAPTKMT2APOLB | |
| SCHEMBL127277 | 0.76 | ALDH1A1 (0.56) | KDM4EARMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |