Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.63 |
| ▸ | MMP9 | P14780 | 6/20 | 0.63 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.63 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289803 | 0.93 | ITGB3 (0.59) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL26616349 | 0.93 | MMP2 (0.73) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL26616346 | 0.93 | MMP2 (0.73) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL5189459 | 0.93 | MMP2 (0.73) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL8578884 | 0.87 | MMP2 (0.57) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL8141491 | 0.87 | TDP1 (0.72) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL8141494 | 0.87 | TDP1 (0.72) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL7292784 | 0.85 | F2 (0.57) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL6799543 | 0.85 | MMP2 (0.55) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL6799552 | 0.85 | MMP2 (0.55) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5595999-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5583133-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5532232-A | INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD | HOFFMANN-LA ROCHE INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5260307-A | Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma | HOFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |