Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8919318 | 0.86 | HTT (0.44) | POLBKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9089099 | 0.85 | SMN1; SMN2 (0.43) | POLBKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8920720 | 0.85 | MAPT (0.41) | POLBKMT2AMAPTALDH1A1THRB | |
| SCHEMBL8920031 | 0.83 | ALDH1A1 (0.36) | POLBKMT2AMAPTCDK5CDK5R1 | |
| SCHEMBL8922319 | 0.83 | MAPT (0.43) | POLBKMT2AMAPTALDH1A1THRB | |
| SCHEMBL9228935 | 0.82 | ALDH1A1 (0.37) | POLBKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4601226 | 0.82 | POLB (0.46) | POLBKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8641624 | 0.81 | MAPT (0.46) | KMT2AMAPTALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL4193744 | 0.81 | ALDH1A1 (0.37) | POLBKMT2AMAPTCDK5CDK5R1 | |
| SCHEMBL6755732 | 0.81 | MAPT (0.42) | POLBKMT2AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663366-A | Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair | WELLA AKTIENGESELLSCHAT (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0618902-A1 | PROCESS FOR PRODUCING 4,5-DIAMINO PYRAZOLE DERIVATIVES, THEIR USE FOR COLOURING HAIR AND NOVEL PYRAZOLE DERIVATIVES | Wella Aktiengesellschaft (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1994008969-A1 | PROCESS FOR PRODUCING 4,5-DIAMINO PYRAZOLE DERIVATIVES, THEIR USE FOR COLOURING HAIR AND NOVEL PYRAZOLE DERIVATIVES | WELLA AKTIENGESELLSCHAFT (DE) | 1994-04-28 | — | — | WO | disclosed |