Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917658 | 0.83 | APEX1 (0.54) | XDHMEN1KMT2AALDH1A1APEX1 | |
| SCHEMBL28358900 | 0.81 | XDH (0.49) | XDHVCAM1MAPTKDM4EMEN1 | |
| SCHEMBL28358895 | 0.81 | VCAM1 (0.49) | XDHVCAM1MAPTKDM4EMEN1 | |
| SCHEMBL30849028 | 0.73 | XDH (0.45) | XDHVCAM1MAPTMEN1KMT2A | |
| SCHEMBL5924211 | 0.72 | ESR1 (0.57) | XDHVCAM1MAPTKDM4EMEN1 | |
| SCHEMBL989006 | 0.72 | VCAM1 (0.56) | VCAM1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5734347 | 0.70 | VCAM1 (0.68) | VCAM1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5216905 | 0.70 | TPMT (0.64) | VCAM1MAPTKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9064842 | 0.70 | ESR1 (0.56) | XDHVCAM1MAPTKDM4EMEN1 | |
| SCHEMBL19071923 | 0.70 | VCAM1 (0.55) | XDHVCAM1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| CN-1102527-A | Piperazinocarbonylcarbostyrils as peripheral vasodilators | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | CN | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |