Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920283 | 0.83 | XDH (0.47) | APEX1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL11803755 | 0.79 | CASP6 (0.62) | APEX1CASP6TSHRLMNAHCAR3 | |
| SCHEMBL3009122 | 0.76 | APEX1 (0.50) | APEX1CASP6TSHRLMNAFBP1 | |
| SCHEMBL1144962 | 0.75 | MEN1 (0.41) | TPMTALDH1A1MEN1KMT2AGRIK1 | |
| SCHEMBL30856079 | 0.73 | MAOA (0.45) | APEX1CASP6ALDH1A1MEN1KMT2A | |
| SCHEMBL30848955 | 0.73 | APEX1 (0.44) | APEX1CASP6TSHRLMNAFBP1 | |
| SCHEMBL8919196 | 0.73 | CA12 (0.50) | TSHRLMNATPMTALDH1A1 | |
| SCHEMBL8921146 | 0.73 | DAO (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL16714067 | 0.73 | CASP6 (0.55) | APEX1CASP6TSHRLMNAHCAR3 | |
| SCHEMBL8960516 | 0.72 | CASP6 (0.64) | APEX1CASP6TSHRLMNAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| CN-1102527-A | Piperazinocarbonylcarbostyrils as peripheral vasodilators | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | CN | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |