Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920452 | 1.00 | TSHR (0.48) | TSHRMTNR1AMTNR1BSRCAKR1C1 | |
| SCHEMBL8920444 | 1.00 | TSHR (0.48) | TSHRMTNR1AMTNR1BSRCAKR1C1 | |
| SCHEMBL8350787 | 0.78 | ALDH1A1 (0.49) | TSHRKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL1576590 | 0.78 | TSHR (0.48) | TSHRMTNR1AMTNR1BSRCCES1 | |
| SCHEMBL28492946 | 0.75 | TSHR (0.46) | TSHRMTNR1AMTNR1BSRCKMT2A | |
| SCHEMBL10397770 | 0.75 | AKR1C3 (0.50) | TSHRMTNR1AMTNR1BAKR1C1KMT2A | |
| SCHEMBL10397769 | 0.75 | AKR1C3 (0.50) | TSHRMTNR1AMTNR1BAKR1C1KMT2A | |
| SCHEMBL88322 | 0.74 | ALDH1A1 (0.46) | TSHRMTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL142819 | 0.74 | ALDH1A1 (0.44) | TSHRMTNR1AMTNR1BAKR1C1KMT2A | |
| SCHEMBL8921211 | 0.73 | LMNA (0.54) | KMT2AMEN1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802897-A1 | NOVEL COMPOUNDS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021638-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |