SCHEMBL1576590

SCHEMBL1576590

COC(=O)C(=CC=C(c1ccccc1)c1ccccc1)C(=O)OC

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
LMNA P02545 2/20 0.44
MAPT P10636 2/20 0.44
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
NPSR1 Q6W5P4 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
SRC P12931 1/20 0.41
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
APP P05067 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2446936 0.85 ALDH1A1 (0.45) TSHRLMNAMTNR1AMTNR1B
SCHEMBL28492946 0.82 TSHR (0.46) TSHRLMNAMAPTMTNR1AMTNR1B
SCHEMBL14156332 0.81 MEN1 (0.60) TSHRLMNAMAPTNPSR1CYP1A2
SCHEMBL12320346 0.81 TDP1 (0.42) TSHRLMNAMAPTMTNR1AMTNR1B
SCHEMBL1576722 0.78 POLB (0.46) TSHRLMNAMAPTAPP
SCHEMBL1576724 0.78 POLB (0.46) TSHRLMNAMAPTAPP
SCHEMBL142819 0.78 ALDH1A1 (0.44) TSHRLMNAMAPTMTNR1AMTNR1B
SCHEMBL8920435 0.78 TSHR (0.48) TSHRLMNAMAPTMTNR1AMTNR1B
SCHEMBL8920452 0.78 TSHR (0.48) TSHRLMNAMAPTMTNR1AMTNR1B
SCHEMBL8920444 0.78 TSHR (0.48) TSHRLMNAMAPTMTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2683351-B1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME OREAL (FR) 2019-10-16 EP disclosed
EP-2266531-B1 Cosmetic composition comprising a superabsorbent polymer and an organic UV filter L'ORÉAL (FR) 2017-06-14 EP disclosed
EP-2538914-B1 COSMETIC COMPOSITION COMPRISING A SUPERABSORBENT POLYMER AND AT LEAST A GEMINI SURFACTANT ORÉAL L (FR) 2016-06-15 EP disclosed
US-9364690-B2 Composition comprising a superabsorbent polymer and a gemini surfactant L'OREAL (FR) 2016-06-14 US disclosed
US-20160067160-A1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME OREAL (FR) 2016-03-10 US disclosed
US-20150224046-A1 COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT L'OREAL (FR) 2015-08-13 US disclosed
EP-2482793-B1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT ORÉAL L (FR) 2015-04-22 EP disclosed
US-8716311-B2 Use of piperidine ester derivative as solvent in cosmetic compositions; cosmetic compositions comprising it L'OREAL (FR) 2014-05-06 US disclosed
US-20140056832-A1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'OREAL (FR) 2014-02-27 US disclosed
EP-2683351-A2 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'Oréal (FR) 2014-01-15 EP disclosed
US-20120269746-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2012-10-25 US disclosed
WO-2012119861-A2 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'OREAL (FR) 2012-09-13 WO disclosed
EP-2482791-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'Oréal (FR) 2012-08-08 EP disclosed
EP-2482793-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'Oréal (FR) 2012-08-08 EP disclosed
WO-2011038778-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2011-04-07 WO disclosed
WO-2011038776-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2011-04-07 WO disclosed
US-20100330018-A1 COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT L'OREAL (FR) 2010-12-30 US disclosed
EP-2266531-A1 Cosmetic composition comprising a superabsorbent polymer and an organic UV filter L'Oréal (FR) 2010-12-29 EP disclosed
US-20100143276-A1 Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions L'OREAL (FR) 2010-06-10 US disclosed
EP-2193783-A1 Use of an ester derived from 4-carboxy-2-pyrrolidinone as a solvent in cosmetic compositions; cosmetic compositions containing same L'Oreal (FR) 2010-06-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140056832-A1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME DIMT1, MAT2A, SCD TSHR 4336/4885LMNA 2896/4885MAPT 3962/4885
US-20150224046-A1 COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT KRT18, FABP2, FABP4 TSHR 4652/4885LMNA 1156/4885MAPT 159/4885
US-20160067160-A1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME DIMT1, FADS2, SCD TSHR 4271/4885LMNA 2770/4885MAPT 3804/4885
US-20100330018-A1 COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT KRT18, FABP2, FABP4 TSHR 4652/4885LMNA 1156/4885MAPT 159/4885
US-20120269746-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT DEGS1, CAPN1, PPT1 TSHR 3817/4885LMNA 274/4885MAPT 2822/4885
US-20100143276-A1 Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions FASN, ALOX12, PAH TSHR 3189/4885LMNA 461/4885MAPT 3479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.