Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.52 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166550 | 1.00 | KMT2A (0.57) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL6166547 | 1.00 | KMT2A (0.57) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL12997589 | 0.88 | GAA (0.65) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL4353902 | 0.88 | GAA (0.65) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL17302028 | 0.86 | KMT2A (0.56) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL11815802 | 0.82 | GAA (0.56) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL2476811 | 0.82 | ALDH1A1 (0.56) | KMT2AMEN1GAACYP2C19ALDH1A1 | |
| SCHEMBL7051206 | 0.82 | LTA4H (0.59) | KMT2AMEN1GAAALDH1A1CYP3A4 | |
| SCHEMBL5196405 | 0.82 | CES2 (0.50) | KMT2AMEN1ALDH1A1NAPRTCES2 | |
| SCHEMBL10921132 | 0.82 | GAA (0.56) | KMT2AMEN1GAACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0727998-A4 | OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0727998-A1 | OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013067-A1 | OXAZOLES FOR TREATING CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-18 | — | — | WO | disclosed |