Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389887 | 0.85 | SCN5A (0.47) | CA2CA4CA5ALMNAGGPS1 | |
| SCHEMBL8920392 | 0.83 | LMNA (0.40) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL8928244 | 0.81 | CA2 (0.45) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL21389886 | 0.81 | LMNA (0.46) | CA2CA4CA5AMAPTLMNA | |
| SCHEMBL3836739 | 0.76 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL21389871 | 0.74 | SCN5A (0.47) | LMNAGGPS1HDAC3HDAC1HDAC2 | |
| SCHEMBL157472 | 0.73 | CA2 (0.50) | CA2CA4CA5AALDH1A1LMNA | |
| SCHEMBL2171752 | 0.71 | CA2 (0.71) | CA2CA4CA5AALDH1A1LMNA | |
| SCHEMBL8920494 | 0.70 | ENPP2 (0.57) | HDAC3HDAC1HDAC2NCOR2PLK1 | |
| SCHEMBL8921731 | 0.70 | ENPP2 (0.57) | HDAC3HDAC1HDAC2NCOR2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670493-A | ANGIOGENESIS INHIBITORS | ADIR ET COMPAGNIE (FR) | 1997-09-23 | — | — | US | disclosed |