Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 11/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920632 | 1.00 | CCKBR (0.41) | CCKBRGRIN2BOPRM1ALOX5SMN1; SMN2 | |
| SCHEMBL8919398 | 0.95 | GRIN2B (0.38) | CCKBRGRIN2BOPRM1SMN1; SMN2HSD17B1 | |
| SCHEMBL8919393 | 0.95 | GRIN2B (0.38) | CCKBRGRIN2BOPRM1SMN1; SMN2HSD17B1 | |
| SCHEMBL8921251 | 0.94 | CCKBR (0.41) | CCKBRGRIN2BOPRM1SMN1; SMN2 | |
| SCHEMBL8921257 | 0.94 | CCKBR (0.41) | CCKBRGRIN2BOPRM1SMN1; SMN2 | |
| SCHEMBL8922834 | 0.93 | CCKBR (0.41) | CCKBRGRIN2BOPRM1GAAMAPT | |
| SCHEMBL8922831 | 0.93 | CCKBR (0.41) | CCKBRGRIN2BOPRM1GAAMAPT | |
| SCHEMBL8921200 | 0.93 | GRIN2B (0.37) | CCKBRGRIN2BOPRM1SMN1; SMN2HSD17B1 | |
| SCHEMBL8921207 | 0.93 | GRIN2B (0.37) | CCKBRGRIN2BOPRM1SMN1; SMN2HSD17B1 | |
| SCHEMBL8922436 | 0.93 | OPRM1 (0.35) | CCKBRGRIN2BOPRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |