Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10434007 | 0.89 | KDM4E (0.71) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL10434082 | 0.89 | KDM4E (0.71) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9079885 | 0.87 | TOP2A (0.54) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9079887 | 0.87 | TOP2A (0.54) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9080242 | 0.86 | TOP2A (0.53) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9080247 | 0.86 | TOP2A (0.53) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL10999003 | 0.83 | LMNA (0.65) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL10433860 | 0.82 | TOP2A (0.70) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL10433916 | 0.82 | TOP2A (0.70) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL10727411 | 0.82 | TOP2A (0.70) | TOP2ATOP2BKDM4EADRA2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672600-A | Antimicrobial dithiocarbamoyl quinolones | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| US-5387748-A | Antimicrobial dithiocarbamoyl quinolones | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| WO-1990004591-A1 | NOVEL ANTIMICROBIAL DITHIOCARBAMOYL QUINOLONES | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1990-05-03 | — | — | WO | disclosed |
| EP-0366643-A2 | Novel antimicrobial dithiocarbamoyl quinolones | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-05-02 | — | — | EP | disclosed |