Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HPGD | P15428 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079887 | 1.00 | TOP2A (0.54) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9080242 | 0.97 | TOP2A (0.53) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9080247 | 0.97 | TOP2A (0.53) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL8921051 | 0.87 | TOP2A (0.60) | TOP2ATOP2BKDM4EADRA2BMAPK1 | |
| SCHEMBL9079291 | 0.84 | LMNA (0.48) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL9079284 | 0.84 | LMNA (0.48) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL9080919 | 0.83 | ALDH1A1 (0.57) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL9080479 | 0.83 | KDM4E (0.69) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL9080476 | 0.83 | KDM4E (0.69) | TOP2ATOP2BKDM4EALDH1A1HPGD | |
| SCHEMBL9079798 | 0.82 | LMNA (0.47) | TOP2ATOP2BKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |